WebMD Medical Reference provided in collaboration with The Cleveland Clinic
Many people with arthritis -- especially osteoarthritis -- use supplements to ease the pain of arthritis. Glucosamine and chondroitin are the most well known and best tested. Methyl sulfonylmethane, or MSM, is another supplement used to ease the pain of arthritis, but it has not been through as much rigorous scientific testing.
What Are Glucosamine and Chondroitin?
Glucosamine and chondroitin sulfate are components of normal cartilage. In the body, they are the building blocks for cartilage and appear to stimulate the body to make more cartilage.
There are conflicting studies on glucosamine and chondroitin, some demonstrating a beneficial effect on osteoarthritis pain. Others, including the NIH-sponsored multicenter
Glucosamine/Chrondroitin Arthritis Intervention Trial (GAIT), did not show benefit for the primary outcome measure of osteoarthritis pain measured by WOMAC (Western Ontario and McMacster Universities). However, a smaller subgroup of study participants with moderate to severe pain did show significant relief. Due to the small size of this subgroup, these findings should be confirmed in larger studies.
The supplements, which are available in pharmacies and health food stores without a prescription, are well tolerated and appear to be safe. However, there are no long-term studies to confirm their long-term safety and effectiveness. Many physicians may still recommend a trial of glucosamine at this point, and if there is not apparent improvement by 3 months, it would reasonable to stop the treatment.
It is important to check with your doctor before starting any new treatments. Your doctor can review the other medications you are taking and help you decide whether or not these arthritis supplements are right for you. In addition, always follow the instructions on the medication label. Do not take more of the supplements than is recommended. Continue Reading ...
