Dietary Supplements For Treatment of Arthritis From the Cleveland Clinic

WebMD Medical Reference provided in collaboration with The Cleveland Clinic

Many people with arthritis -- especially osteoarthritis -- use supplements to ease the pain of arthritis. Glucosamine and chondroitin are the most well known and best tested. Methyl sulfonylmethane, or MSM, is another supplement used to ease the pain of arthritis, but it has not been through as much rigorous scientific testing.

What Are Glucosamine and Chondroitin?

Glucosamine and chondroitin sulfate are components of normal cartilage. In the body, they are the building blocks for cartilage and appear to stimulate the body to make more cartilage.
There are conflicting studies on glucosamine and chondroitin, some demonstrating a beneficial effect on osteoarthritis pain. Others, including the NIH-sponsored multicenter

Glucosamine/Chrondroitin Arthritis Intervention Trial (GAIT), did not show benefit for the primary outcome measure of osteoarthritis pain measured by WOMAC (Western Ontario and McMacster Universities). However, a smaller subgroup of study participants with moderate to severe pain did show significant relief. Due to the small size of this subgroup, these findings should be confirmed in larger studies.

The supplements, which are available in pharmacies and health food stores without a prescription, are well tolerated and appear to be safe. However, there are no long-term studies to confirm their long-term safety and effectiveness. Many physicians may still recommend a trial of glucosamine at this point, and if there is not apparent improvement by 3 months, it would reasonable to stop the treatment.

It is important to check with your doctor before starting any new treatments. Your doctor can review the other medications you are taking and help you decide whether or not these arthritis supplements are right for you. In addition, always follow the instructions on the medication label. Do not take more of the supplements than is recommended. Continue Reading ...

All About Osteoarthritis and Women

By Jeanie Lerche Davis

WebMD Feature

Reviewed By Charlotte Mathis, MD

If you've just been diagnosed with osteoarthritisosteoarthritis (OA), you're not alone. Many women past age 50 discover OA is the reason for their creaking knees, aching backs, and sore fingers. Suddenly life is all about osteoarthritis -- but luckily, arthritisarthritis doesn't have to take control.

Arthritis is "the most common form of disability. It's also a natural part of aging," says Primal Kaur, MD, director of the Osteoporosis Clinic at Temple University School of Medicine in Philadelphia.

In the U.S., one in five adults has osteoarthritis -- 24 million women and 17 million men, according to the Arthritis Foundation. Continue Reading ...

Omega-3s Revealed

Researchers have long known omega-3 fatty acids help reduce inflammation. Now they know how.

by Linda RichardsPosted 2/12/07

Understanding how your body benefits from eating omega-3 fatty acids is an important part of understanding why you should eat them. But, until recently, no one really knew what made omega-3s so beneficial. Researchers, however, have uncovered the secret of omega-3 fatty acids. A study at Brigham and Women’s Hospital in Boston revealed that omega-3s actually convert into compounds that are 10,000 times more potent than the original fatty acids themselves. So what does this mean to us? The new compounds include resolvins, which help bring the inflammatory response to an end, says the study’s lead researcher, Charles Serhan, PhD, director, Center for Experimental Therapeutics and Reperfusion Injury at Harvard Medical School, Boston. Continue reading ...

New Drug for Arthritis?

New drug for arthritis?: Merck seeking FDA approval for Arcoxia, a chemical relative of Vioxx, which was linked to heart attacks

Kathleen Kerr, Newsday, Melville, N.Y.

Mar. 21, 2007 -- In a bid to recapture a piece of the arthritis pain-relief market, Merck & Co. is seeking government approval for Arcoxia, a chemical relative of Vioxx, the drug pulled off drugstore shelves in 2004 after being linked to heart attacks.

In its last full year on the market, Vioxx brought in about $2.5billion in sales. If the Food and Drug Administration approves Arcoxia, Merck could recoup some of those sales.

On April 12 an FDA advisory panel will consider approval of Arcoxia for osteoarthritis; it is already sold in 62 other countries. The FDA usually follows advisory panel recommendations. Continue reading ...

FDA Whistle Blower Blasts New Arthritis Drug

FDA whistle-blower Graham blasts new Merck arthritis drug

Updated 9/12/2006 9:51 PM ET

By Rita Rubin, USA TODAY / Health & Behavior

The arthritis drug that Merck has developed to compete with Celebrex may be as risky for the heart as Vioxx, writes Food and Drug Administration whistle-blower David Graham in an editorial posted online Tuesday by a medical journal.

In considering whether Arcoxia should be approved, "the FDA, academia, and the medical research enterprise are once again faced with the opportunity to forsake common sense by willfully accepting misdirection and disinformation presented in the guise of science," Graham writes on the Journal of the American Medical Association's website. Continue reading ...

Massage May Help Knee Osteoarthritis

Less Knee Pain and Stiffness Seen With Swedish Massage in Preliminary Study By Miranda Hitti

WebMD Medical News Reviewed By Louise Chang, MD
on Monday, December 11, 2006

Can A Massage Improve Your Health?

Dec. 11, 2006 -- Knees hurt? Massage may cut the pain and improve function if you have knee osteoarthritisosteoarthritis, a new study shows.

Massage therapy "seems to be a viable option" as an addition to other treatments for osteoarthritis of the knee, write the researchers.

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